a prefix occurring in loanwords from Greek, where it meant “upon,” “on,” “over,” “near,” “at,” “before,” “after” (epicedium; epidermis; epigene; epitome ); on this model, used in the formation of new compound words (epicardium; epinephrine ).
Also, ep-, eph-.

< Greek, prefixal use of epí, preposition and adv.

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World English Dictionary
epi-, (before a vowel) eph- or (before a vowel) ep-
1.  on; upon; above; over: epidermis; epicentre
2.  in addition to: epiphenomenon
3.  after: epigenesis; epilogue
4.  near; close to: epicalyx
[from Greek, from epi (prep)]
eph-, (before a vowel) eph- or (before a vowel) ep-
[from Greek, from epi (prep)]
ep-, (before a vowel) eph- or (before a vowel) ep-
[from Greek, from epi (prep)]

Collins English Dictionary - Complete & Unabridged 10th Edition
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Word Origin & History

from Gk. epi "upon, at, close upon (in space or time), on the occasion of, in addition" (cognate with Skt. api "also, besides;" Avestan aipi "also, to, toward;" Arm. ev "also, and;" L. ob "toward, against, in the way of"). Before unaspirated vowels, reduced to ep-; before aspirated vowels, eph-. Used
in modern scientific compounds, cf. epicenter; epicycle (late 14c.).
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

epi- or ep-

  1. On; upon: epineural.

  2. Over; above: epibasal.

  3. Around: epicystitis.

  4. Close to; near: epimer.

  5. Besides: epiphenomenon.

  6. After: epigenesis.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences
Individual sites could theoretically block out these epi-networks, but at their peril.
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