esophagoptosis e·soph·a·gop·to·sis (ĭ-sŏf'ə-gŏp-tō'sĭs, -gō-tō'sĭs) or e·soph·a·gop·to·si·a (-tō'sē-ə, -zē-ə) n. Relaxation and downward displacement of the walls of the esophagus.