eye·strain (ī'strān') n. Pain and fatigue of the eyes, often accompanied by headache, resulting from prolonged use of the eyes, uncorrected defects of vision, or an imbalance of the eye muscles.
eyestrain eye·strain (ī'strān') n. Pain and fatigue of the eyes, often accompanied by headache, due to prolonged use of the eyes, uncorrected defects of vision, or an imbalance of the eye muscles. Also called asthenopia.