noun Informal.
a fraudulent incrimination of an innocent person.

1895–1900, Americanism; frame + up, modeled on nominalizations of phrasal verbs, with up as perfective particle Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
1.  a conspiracy to incriminate someone on a false charge
2.  a plot to bring about a dishonest result, as in a contest

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Slang Dictionary

frame definition

  1. tv.
    to cause an innocent person to be blamed for a crime; to contrive evidence so that someone appears to be guilty. (Originally underworld.) : Jimmy tried to frame his sister for painting the cat yellow.
  2. n.
    and frame-up; frameup. a scheme where an innocent person is made to take the blame for something; incrimination caused by contrived evidence. (Underworld.) : The frame-up would have worked if it weren't for one little thing.
Dictionary of American Slang and Colloquial Expressions by Richard A. Spears.Fourth Edition.
Copyright 2007. Published by McGraw-Hill Education.
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Example sentences
Indeed, it suggests they are a rogue cell calling a midnight caucus for a frame-up.
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