The hole in his chest through which the drug flowed required some fussing, but there was no discomfort.
We waited and waited, and Boris, growing restless, wandered about, fussing with modelling wax and red clay.
I start by holding my glasses in my hand instead of fussing with the mask.
1701, perhaps an alteration of force, or imitative of bubbling or sputtering sounds, or from Danish fjas "foolery, nonsense." First attested in Anglo-Irish writers, but no obvious connections to Irish. To make a fuss was earlier to keep a fuss (1726).
1792, from fuss (n.). Related: Fussed; fussing.