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gargoylism

[gahr-goi-liz-uh m] /ˈgɑr gɔɪˌlɪz əm/
noun, Pathology
1.
a congenital abnormality characterized chiefly by dwarfism, grotesque deformities of the head, trunk, and limbs, mental retardation, and enlargement of the liver and spleen.
Origin
1935-1940
1935-40; gargoyle + -ism
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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gargoylism in Medicine

gargoylism gar·goyl·ism (gär'goil'ĭz'əm)
n.
A condition characterized by coarsened facial surface and distorted features and associated with Hurler's syndrome and Hunter's syndrome.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Encyclopedia Article for gargoylism

one of several rare genetic disorders involving a defect in the metabolism of mucopolysaccharides, the class of polysaccharides that bind water to unite cells and to lubricate joints. Onset of the syndrome is in infancy or early childhood, and the disease occurs with equal frequency in both sexes. Affected individuals exhibit severe mental retardation, clouding of the corners of the eyes, deafness, hirsutism (hairiness), enlarged liver and spleen, dwarfism with hunched back, short limbs and clawed hands, a large head with wide-set eyes, heavy brow ridges and deep bridge of nose, and poorly formed teeth. The disorder is identifiable within two years of birth; such children require institutional care and usually do not live beyond adolescence. Death most often results from heart failure, which is attributable to infiltration of heart muscle and coronary vessels with mucopolysaccharides.

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Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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