general paralysis of the insane

World English Dictionary
general paralysis of the insane
 
n
GPI, general paresis, Also called: dementia paralytica a disease of the central nervous system: a late manifestation of syphilis, often occurring up to 15 years after the original infection, characterized by mental deterioration, speech defects, and progressive paralysis

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Encyclopedia Britannica
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general paralysis of the insane

psychosis caused by widespread destruction of brain tissue occurring in some cases of late syphilis. Mental changes include gradual deterioration of personality, impaired concentration and judgment, delusions, loss of memory, disorientation, and apathy or violent rages. Convulsions are not uncommon, and while temporary remissions sometimes occur, untreated paresis is eventually fatal.

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Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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