general paralysis

noun Pathology.
a syphilitic brain disorder characterized by chronic inflammation and degeneration of cerebral tissue resulting in mental and physical deterioration.
Also called general paresis.

1890–95 Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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Symptoms include paralysis of the arms and legs, followed by a general paralysis which can be fatal if not reversed.
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