1. Ghost, specter, spirit all refer to the disembodied soul of a person. A ghost is the soul or spirit of a deceased person, which appears or otherwise makes its presence known to the living: the ghost of a drowned child. A specter is a ghost or apparition of more or less weird, unearthly, or terrifying aspect: a frightening specter. Spirit is often interchangeable with ghost but may mean a supernatural being, usually with an indication of good or malign intent toward human beings: the spirit of a friend; an evil spirit.

Did you mean give up the ghost?