Medical Dictionary
Main Entry:
Hand–Schül·ler–Chris·tian disease Pronunciation:
"hand-"shü-l&r-'kris(h)-ch&n- Function:
noun : aninflammatory histiocytosis associated with disturbances in cholesterol metabolism that occurs chiefly in young children and is marked by cystic defects of the skull and by exophthalmos and diabetesinsipidus called also
Schüller-Christian disease Hand, Alfred (1868–1949), American physician. Hand published an early description of the disease in 1893. Hisdescription referred to it as a condition characterized by polyuria and tuberculosis. The condition was earlier observed, however, by the British pathologist Thomas Smith (1833–1909) in 1865 and1876.
Schüláler /'sh[ue]l-&r/,
Artur (1874–1958), Austrian neurologist. Schüller offered his description of the disease in 1915. His descriptionwas based on two additional cases and noted the defects in the membranous bones.
Christian, Henry Asbury (1876–1951), American physician. Christian gave a more completedescription in 1919 which included all the major characteristics.
