a tendency to use one hand more than the other.

1920–25; handed + -ness

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World English Dictionary
handedness (ˈhændɪdnɪs)
1.  the tendency to use one hand more skilfully or in preference to the other
2.  dextrorotation See also laevorotation the property of some chemical substances of rotating the plane of polarized light in one direction rather than another
3.  See also helicity the relation between the vectors of spin and momentum of neutrinos and certain other elementary particles

Collins English Dictionary - Complete & Unabridged 10th Edition
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American Heritage
Medical Dictionary

handedness hand·ed·ness (hān'dĭd-nĭs)

  1. A preference for using one hand as opposed to the other.

  2. The chirality of a molecule.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Science Dictionary
handedness   (hān'dĭd-nĭs)  Pronunciation Key 
  1. A preference for using one hand rather than the other to perform most manual tasks and activities. Most people are right-handed. Historically, it has been theorized that handedness is associated with a dominance of the opposite cerebral hemisphere of the brain, but this has not been conclusively proven. Although the scientific basis for handedness is unknown, the fact that left-handed parents more frequently have left-handed offspring suggests at least a partial genetic component. Some experts believe that children are trained to favor one hand over the other (usually the right hand.). Handedness is usually established in the first few years of life.

  2. See chirality.

The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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Example sentences
And our right or left handedness corresponds with the brain localization of
Handedness is one of the enduring mysteries of life.
It even showed the same handedness that the eyes of sighted people have for
B-modes retain their special nature as manifest in the fact that they can
  possess a handedness that distinguishes left from right.
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