Misfortune, adversity, as in He's had a lot of hard luck in his day. This expression is also used in the phrase hard-luck story, a tale of one's misfortune that is related in order to get sympathy (or a donation). For example, We can't ignore her hard-luck story, even if you doubt that it's true. [Second half of 1500s] Also see tough break.
Dictionary.com presents 366 FAQs, incorporating some of the frequently asked questions from the past with newer queries.