extremely depressed or unhappy.

1520–30; heart + sick1

heartsickening, adjective
heartsickness, noun

dejected, sick-at-heart, despondent, dispirited.
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World English Dictionary
heartsick (ˈhɑːtˌsɪk)
deeply dejected or despondent

Collins English Dictionary - Complete & Unabridged 10th Edition
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Example sentences
With predictable complements of heartsick teenagers, busybody servants and oppressive guardians, they could easily fall into rote.
He appears to be more distracted than heartsick or emotionally undone.
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