his·to·plas·mo·sis (hĭs'tō-plāz-mō'sĭs) n.
pl.his·to·plas·mo·ses (-sēz) A disease caused by the inhalation of spores of the fungus Histoplasma capsulatum, most often asymptomatic but occasionally producing acute pneumonia or an influenzalike illness and spreading to other organs and systems in the body.