|baseball a hit that enables the batter to run round all four bases, usually by hitting the ball out of the playing area|
|a calculus or concretion found in the stomach or intestines of certain animals, esp. ruminants, formerly reputed to be an effective remedy for poison.|
|an extraordinary or unusual thing, person, or event; an exceptional example or instance.|
A highly successful achievement; also, doubling one's profits. For example, We scored a home run with that drug stock, buying it at 15 and selling at 30. This expression originated in the mid-1800s in baseball, where it refers to a pitched ball batted so far that the batter can round all three bases and reach home plate, scoring a run. Its figurative use dates from the mid-1900s.