1. irremediable, remediless, incurable. 2. forlorn, disconsolate, dejected. Hopeless, despairing, despondent, desperate all describe an absence of hope. Hopeless is used of a feeling of futility and passive abandonment of oneself to fate: Hopeless and grim, he still clung to the cliff. Despairing refers to the loss of hope in regard to a particular situation, whether important or trivial; it suggests an intellectual judgment concerning probabilities: despairing of victory; despairing of finding his gloves. Despondent always suggests melancholy and depression; it refers to an emotional state rather than to an intellectual judgment: Despondent over ill health, he killed himself. She became despondent and suspicious. Desperate conveys a suggestion of recklessness resulting from loss of hope: As the time grew shorter, he became desperate. It may also refer to something arising from extreme need or danger: a desperate remedy; a desperate situation. Despairing and despondent may apply only to feelings.