Hous·ton (hyōō'stən) A city of southeast Texas northwest of Galveston. Founded in 1836 and named for Sam Houston, it is a major industrial, commercial, and financial hub, the center of the U.S. aerospace industry, and a deep-water port connected with Galveston Bay and the Gulf of Mexico by the Houston Ship Channel. Houston is also the largest city in Texas. Population: 2,140,000. Hous·to'ni·an (hyōō-stō'nē-ən) n.