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hyperaldosteronism hy·per·al·dos·ter·on·ism (hī'pər-āl-dŏs'tə-rō-nĭz'əm, -āl'dō-stěr'ə-)
increased secretion of the hormone aldosterone by the cells of the zona glomerulosa (the outer zone) of the adrenal cortex. The primary actions of aldosterone are to increase retention of salt and water and to increase excretion of potassium by the kidneys and to a lesser extent by the skin and intestine. Hyperaldosteronism may be classified as primary or secondary. Primary hyperaldosteronism (primary aldosteronism) is the unregulated secretion of aldosterone due to an adrenal tumour or hyperplasia of both adrenal glands. The tumours are nearly always benign (adenoma). Secondary hyperaldosteronism (secondary aldosteronism) is caused by disorders that result in loss of sodium (salt) and water from the body and decreased blood flow to the kidneys.