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[hahy-per-ker-uh-toh-sis] /ˌhaɪ pərˌkɛr əˈtoʊ sɪs/
  1. proliferation of the cells of the cornea.
  2. a thickening of the horny layer of the skin.
Also called x-disease. Veterinary Pathology. a disease of cattle resulting from their physical contact with or eating of objects or food contaminated by wood preservatives or machinery lubricants containing highly chlorinated naphthalenes, characterized by thickening and hardening of the skin, abnormal secretion of tears and saliva, and diarrhea.
1835-45; < New Latin; see hyper-, keratosis
Related forms
[hahy-per-ker-uh-tot-ik] /ˌhaɪ pərˌkɛr əˈtɒt ɪk/ (Show IPA),
adjective Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2015.
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British Dictionary definitions for hyperkeratosis


(pathol) overgrowth and thickening of the outer layer of the skin
Derived Forms
hyperkeratotic (ˌhaɪpəˌkɛrəˈtɒtɪk) adjective
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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hyperkeratosis in Medicine

hyperkeratosis hy·per·ker·a·to·sis (hī'pər-kěr'ə-tō'sĭs)
n. pl. hy·per·ker·a·to·ses (-sēz)
Hypertrophy of the cornea or the horny layer of the skin. Also called hyperkeratinization.

hy'per·ker'a·tot'ic (-tŏt'ĭk) adj.
The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Encyclopedia Article for hyperkeratosis

in cattle, a disease characterized by inflammation and thickening of the horny covering of the epidermis, the outermost layer of the skin. Other symptoms include weight loss, wartlike swellings in the mouth, drooling, and a runny nose. Severely afflicted animals usually die. Although once attributed to a virus, the disease is now known to be caused by the ingestion of feed contaminated with chlorinated naphthalene, a lubricant used to grease feed mills. The term hyperkeratosis is also used to describe the hypertrophy of the corneous layer of the human skin.

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Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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