idioheteroagglutinin id·i·o·het·er·o·ag·glu·ti·nin (ĭd'ē-ō-hět'ə-rō-ə-gl&oomacr;t'n-ĭn) n. An idioagglutinin occurring in the blood of one animal, but capable of combining with the antigenic material from an animal of another species.