1560, from L.
insanus "mad, insane, outrageous, excessive, extravagant," from
in- "not" +
sanus (see
sane). Originally only of persons; of actions, from 1842. Cf.
lunatic; and It.
pazzo "insane," originally a euphemism, from L.
patiens "suffering." Ger.
verrückt, lit. pp. of
verrücken "to displace," "applied to the brain as to a clock that is 'out of order' " [Buck].