"You canker blossom!" 3 Shakespearean Insults
c.1400, intoxigacion "poisoning," from Medieval Latin intoxicationem (nominative intoxicatio) "poisoning," noun of action from past participle stem of intoxicare (see intoxicate). Meaning "drunkenness" is from 1640s.
intoxication in·tox·i·ca·tion (ĭn-tŏk'sĭ-kā'shən)
The pathological state produced by a drug, serum, alcohol, or any toxic substance; poisoning.
A state of mental excitement or emotional frenzy.