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iproniazid

[ahy-pruh-nahy-uh-zid] /ˌaɪ prəˈnaɪ ə zɪd/
noun, Pharmacology
1.
a compound, C 9 H 13 N 3 O, used in the treatment of mental depression and tuberculosis.
Origin
1950-1955
1950-55; i(so)pro(pyl) + ni(cotine) + az- + -id4
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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iproniazid in Medicine

iproniazid i·pro·ni·a·zid (ī'prə-nī'ə-zĭd)
n.
A compound used as an antidepressant and formerly used in the treatment of tuberculosis.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Encyclopedia Article for iproniazid

the first drug of the monoamine-oxidase inhibitor series to be introduced into medicine (1958). It was employed as an antidepressant until it was found to cause liver damage. Prior to its introduction as an antidepressant, iproniazid was studied as a drug similar in function to the antituberculotic drug isoniazid, which it resembles in chemical structure. It prevents the enzymatic breakdown of norepinephrine, the brain-neurotransmitter substance concerned with emotional stimulation. It does so by inhibiting the enzyme monoamine oxidase.

Learn more about iproniazid with a free trial on Britannica.com
Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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