irreversible

[ir-i-vur-suh-buhl]
adjective
not reversible; incapable of being changed: His refusal is irreversible.

Origin:
1620–30; ir-2 + reversible

irreversibility, irreversibleness, noun
irreversibly, adverb
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World English Dictionary
irreversible (ˌɪrɪˈvɜːsəbəl)
 
adj
1.  not able to be reversed: the irreversible flow of time
2.  not able to be revoked or repealed; irrevocable
3.  chem, physics capable of changing or producing a change in one direction only: an irreversible reaction
4.  thermodynamics (of a change, process, etc) occurring through a number of intermediate states that are not all in thermodynamic equilibrium
 
irreversi'bility
 
n
 
irre'versibleness
 
n
 
irre'versibly
 
adv

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Example sentences
Some would-be duelists discovered that even the code's formal preliminaries
  might set in motion an irreversible chain of events.
Look, the labels know that recorded music is in irreversible decline.
Most scientists agree that beyond some critical threshold, climate change is
  irreversible and probably catastrophic.
The intellectual break with the past was drastic and seemingly irreversible.
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