the act of irritating or the state of being irritated.
something that irritates.
Physiology, Pathology.
the bringing of a bodily part or organ to an abnormally excited or sensitive condition.
the condition itself.

1580–90; < Latin irrītātiōn- (stem of irrītātiō). See irritate, -ion

aggravation, annoyance, intensification, irritation, worsening. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
irritation (ˌɪrɪˈteɪʃən)
1.  something that irritates
2.  the act of irritating or the condition of being irritated

Collins English Dictionary - Complete & Unabridged 10th Edition
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American Heritage
Medical Dictionary

irritation ir·ri·ta·tion (ĭr'ĭ-tā'shən)

  1. Extreme incipient inflammatory reaction of the body tissues to an injury.

  2. The normal response of a nerve or muscle to a stimulus.

  3. The evocation of a reaction in the body tissues by the application of a stimulus.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences
All the time he had been in a state of ill-concealed irritation at the noise of
  the vivisected puma.
The leaves can cause irritation, so protect your skin.
The plant's fuzzy hairs can cause a skin irritation in some susceptible people.
Whether it's successful or not, its expression of perpetual irritation will
  never change.
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