noun Cell Biology.
Also called chromocenter. any of several masses of chromatin in the reticulum of a cell nucleus.
a chromosome.

1885–90; karyo- + -some3

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World English Dictionary
karyosome (ˈkærɪəʊˌsəʊm)
1.  any of the dense aggregates of chromatin in the nucleus of a cell
2.  the nucleus of a cell

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American Heritage
Medical Dictionary

karyosome kar·y·o·some (kār'ē-ə-sōm')
An aggregation of chromatin in the nucleus of a cell not undergoing mitosis.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences
Trophozoites possess a single nucleus that contains a small, centrally-located karyosome and fine peripheral chromatin.
The karyosome is pleomorphic, and may be minute to large and compact to diffuse, and centrally or eccentrically-located.
Trophozoites contain a large nucleus with a large, centrally-located karyosome but no peripheral chromatin.
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