last straw

noun
the last of a succession of irritations, incidents, remarks, etc., that leads to a loss of patience, a disaster, etc.: He has been late before, but this is the last straw.

Origin:
1840–50; after the proverb “It is the last straw that breaks the camel's back”

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World English Dictionary
last straw
 
n
the last straw the final irritation or problem that stretches one's endurance or patience beyond the limit
 
[from the proverb, "It is the last straw that breaks the camel's back"]

Collins English Dictionary - Complete & Unabridged 10th Edition
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Example sentences
The last impact is then the last straw for an already compromised brain.
The rare earths controversy was kind of a last straw.
That's why pneumonia is the last straw for many measles-infected infants.
Gray insists that that one image was the last straw.
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