If Romney loses Ohio and its 18 electoral votes, it is very difficult to win the White House.
If Assad falls and a new government is formed by Sunni rebel forces, Iran loses a keystone in its regional power structure.
If that happens, the GOP loses everything it gained in November of 2010.
Old English losian "be lost, perish," from los "destruction, loss," from Proto-Germanic *lausa- (cf. Old Norse los "the breaking up of an army;" Old English forleosan "to lose, destroy," Old Frisian forliasa, Old Saxon farliosan, Middle Dutch verliesen, Old High German firliosan, German verlieren), from PIE root *leu- "to loosen, divide, cut apart, untie, separate" (cf. Sanskrit lunati "cuts, cuts off," lavitram "sickle;" Greek lyein "to loosen, untie, slacken," lysus "a loosening;" Latin luere "to loose, release, atone for, expiate").
Replaced related leosan (a class II strong verb whose past participle loren survives in forlorn and lovelorn), from Proto-Germanic *leusanan (cf. Old High German virliosan, German verlieren, Old Frisian urliasa, Gothic fraliusan "to lose").
Transitive sense of "to part with accidentally" is from c.1200. Meaning "fail to maintain" is from mid-15c. Meaning "to be defeated" (in a game, etc.) is from 1530s. Meaning "to cause (someone) to lose his way" is from 1640s. To lose (one's) mind "become insane" is attested from c.1500. To lose out "fail" is 1858, American English. Related: Lost; losing.