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First recorded in 1350–1400.
Comes via Middle English from the Latin word tortuōsus, which derives from the verb torquēre, “to twist, bend.”
Sign up for more Word of the Day!

\r\nEXAMPLES OF TORTUOUS\r\n

The tortuous road through the mountains made for a challenging but scenic drive.
The author's writing style was known for its elegant prose and tortuous plot twists.

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Did you mean macrophage?