magnum opus

a great work, especially the chief work of a writer or artist: Proust's magnum opus is Remembrance of Things Past.

1785–95; < Latin Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
magnum opus
a great work of art or literature, esp the greatest single work of an artist

Collins English Dictionary - Complete & Unabridged 10th Edition
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Word Origin & History

magnum opus
"masterpiece," from L., lit. "great work" (see magnum + opus).
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Cultural Dictionary
magnum opus [(mag-nuhm oh-puhs)]

The most important work in a person's career, especially in literature, art, or scholarship: “Moby Dick was Melville's magnum opus.” From Latin, meaning “great work.”

The American Heritage® New Dictionary of Cultural Literacy, Third Edition
Copyright © 2005 by Houghton Mifflin Company.
Published by Houghton Mifflin Company. All rights reserved.
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Example sentences
You'd think that the omnipotent creator would have mentioned such a thing in its magnum opus.
He had the credentials before he wrote his magnum opus.
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