noun Computers.
a large computer, often the hub of a system serving many users.

1960–65; main1 + frame Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
mainframe (ˈmeɪnˌfreɪm)
1.  a.  a high-speed general-purpose computer, usually with a large storage capacity
 b.  (as modifier): mainframe systems
2.  the central processing unit of a computer

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

"central processor of a computer system," 1964, from main (adj.) + frame.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Science Dictionary
mainframe   (mān'frām')  Pronunciation Key 
A large, often powerful computer, usually dedicated to lengthy, complex calculations or set up for use by many people simultaneously. Compare personal computer.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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American Heritage
Cultural Dictionary

mainframe definition

A large, powerful computer system. A mainframe computer typically carries out complex calculations and is shared by many users. (Compare personal computer.)

The American Heritage® New Dictionary of Cultural Literacy, Third Edition
Copyright © 2005 by Houghton Mifflin Company.
Published by Houghton Mifflin Company. All rights reserved.
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Example sentences for mainframes
Mainframes also have execution integrity characteristics for fault tolerant computing.
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