the act of manipulating.
the state or fact of being manipulated.
skillful or artful management.

1720–30; < French, equivalent to manipule handful (of grains, etc.; see maniple) + -ation -ation Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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Word Origin & History

c.1730, "a method of digging ore," from Fr. manipulation, from manipule "handful" (a pharmacists' measure), from L. manipulus "handful, sheaf," from manus "hand" (see manual) + root of plere "to fill" (see plenary). Sense of "skillful handling
of objects" is first recorded 1826; extended 1828 to "handling of persons" as well as objects.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

manipulation ma·nip·u·la·tion (mə-nĭp'yə-lā'shən)

  1. The act or the practice of manipulating.

  2. The state of being manipulated.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences for manipulations
He invented modular arithmetic, greatly simplifying manipulations in number theory.
But describing manipulations in noncausal terms has provided a substantial difficulty.
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