the original text of an author's work, handwritten or now usually typed, that is submitted to a publisher.
any text not printed.
a book or document written before the invention of printing.
writing, as distinguished from print.
handwritten or typed, not professionally printed.

1590–1600; < Medieval Latin manūscrīptus written by hand, equivalent to Latin manū by hand (ablative of manus) + scrīptus written; see script

manuscriptal, adjective Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
manuscript (ˈmænjʊˌskrɪpt)
1.  a book or other document written by hand
2.  the original handwritten or typed version of a book, article, etc, as submitted by an author for publication
3.  a.  handwriting, as opposed to printing
 b.  (as modifier): a manuscript document
[C16: from Medieval Latin manūscriptus, from Latin manus hand + scribere to write]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

1597, from M.L. manuscriptum, from L. manu scriptus "written by hand," from manu, abl. of manus "hand" (see manual) + scriptus, pp. of scribere "to write" (see script). Abbreviation is MS, plural MSS.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
No pictures, no musical manuscripts, nor anything much that once belonged to a
  great composer.
It also highlights one of the big problems with bringing old manuscripts into
  the modern age.
The so-called octavo format was a departure from previous manuscripts because
  it was handy, portable, and pocket-size.
Professional editors then read the full manuscripts of high-scoring books.
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