marble bone disease

Medical Dictionary

marble bone disease mar·ble bone disease (mär'bəl)
n.
See osteopetrosis.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
Cite This Source
Encyclopedia Britannica
Encyclopedia

marble bone disease

rare hereditary congenital disorder in which the bones become extremely dense, hard, and brittle. The disease progresses as long as bone growth continues; the marrow cavities become filled with compact bone, and severe anemia results. In marble bone disease, bone-resorbing cells called osteoclasts are either reduced in number or are ineffective. Fractures are frequent; deafness and loss of vision may occur because cranial nerves become compressed by the narrowing of their passageways as bone is deposited in the skull. Severe cases may be fatal; individuals with mild cases of the disorder may have a normal life expectancy. Treatment may include gamma interferon, a protein that delays progression of the disease; bone marrow transplantation; or calcitriol, a vitamin D compound that stimulates osteoclasts to dissolve and absorb bone.

Learn more about marble bone disease with a free trial on Britannica.com.

Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
Cite This Source
Copyright © 2014 Dictionary.com, LLC. All rights reserved.
  • Please Login or Sign Up to use the Recent Searches feature