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1918, altered by influence of Spanish proper name Maria Juana "Mary Jane" from mariguan (1894), from Mexican Spanish marihuana, of uncertain origin.
Marijuana ... makes you sensitive. Courtesy has a great deal to do with being sensitive. Unfortunately marijuana makes you the kind of sensitive where you insist on everyone listening to the drum solo in Iron Butterfly's 'In-a-Gadda-Da-Vida' fifty or sixty times. [P.J. O'Rourke, "Modern Manners," 1983]
marijuana mar·i·jua·na or mar·i·hua·na (mār'ə-wä'nə)
The cannabis plant.
A preparation made from the dried flower clusters and leaves of the cannabis plant, usually smoked or eaten to induce euphoria.