1560s, from L. masticationem (nom. masticatio), from masticare "to chew" (cf. O.Fr. maschier, Fr. mâcher), probably from Gk. mastikhan "to gnash the teeth," related to mastax "mouth, jaws," and masasthai "to chew," from PIE *menth- "to chew, mouth" (cf. L. mandere "to chew," Goth. munþs, O.E. muð "mouth").
1640s, from L.L. masticat-, pp. stem of masticare (see mastication). Related: Masticated; masticating.