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methotrexate

[meth-oh-trek-seyt] /ˌmɛθ oʊˈtrɛk seɪt/
noun, Pharmacology
1.
a toxic folic acid analogue, C 2 0 H 2 2 N 8 O 5 , that inhibits cellular reproduction, used primarily in the treatment of psoriasis and certain cancers and as an immunosuppressive agent.
Origin
1950-1955
1950-55; metho(xy)- + trexate, of unclear derivation
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Based on the Random House Dictionary, © Random House, Inc. 2014.
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Examples from the web for methotrexate
  • These medicines include corticosteroids, cyclosporine, and methotrexate.
British Dictionary definitions for methotrexate

methotrexate

/ˌmɛθəʊˈtrɛkseɪt; ˌmiːθəʊ-/
noun
1.
an antimetabolite drug used in the treatment of certain cancers. Formula: C20H22N8O5
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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methotrexate in Science
methotrexate
  (měth'ə-trěk'sāt)   
A toxic drug that acts as a folic acid antagonist to interfere with cellular reproduction and is used in the treatment of psoriasis, certain cancers, and certain inflammatory diseases, such as rheumatoid arthritis. Chemical formula: C20H22N8O5.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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Encyclopedia Article for methotrexate

drug used to slow the growth of certain cancers, including leukemia, breast cancer, and lung cancer. It is also used in the treatment of rheumatoid arthritis and psoriasis, a skin disease in which abnormally rapid proliferation of epidermal cells occurs. Methotrexate is an antimetabolite of the B vitamin folic acid (folate). It prevents the synthesis of nucleic acids and thus inhibits cell reproduction. This property also makes it effective as an agent of medical abortion, either for the termination of ectopic pregnancy or of normal intrauterine pregnancy during the first seven to nine weeks.

Learn more about methotrexate with a free trial on Britannica.com
Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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