middle age

noun
the period of human life between youth and old age, sometimes considered as the years between 45 and 65 or thereabout.

Origin:
1350–1400; Middle English

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Collins
World English Dictionary
middle age
 
n
the period of life between youth and old age, usually (in man) considered to occur approximately between the ages of 40 and 60

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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American Heritage
Medical Dictionary

middle age mid·dle age (mĭd'l)
n.
The time of human life between youth and old age, usually reckoned as the years between 40 and 60. Also called midlife.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Encyclopedia Britannica
Encyclopedia

middle age

period of human adulthood that immediately precedes the onset of old age. Though the age period that defines middle age is somewhat arbitrary, differing greatly from person to person, it is generally defined as being between the ages of 40 and 60. The physiological and psychological changes experienced by a middle-aged person centre on the gradual decline of physical abilities and the awareness of mortality. In middle age, the relative potencies of past, present, and future are altered as the individual increasingly directs effort to the process of reminiscence and recollection of the past, rather than anticipation of the future. If approached constructively, middle age can prepare an individual for a satisfying and productive old age. See also psychological development.

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Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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Example sentences
And despite encroaching middle age and far too many premature deaths, they have
  remained enshrined as such ever since.
Some of the gift ideas could be given to older kids, or even adults, but they
  are mostly aimed at the middle age kids.
When he did that in middle age, he gave the mice many more healthy years.
Bars may form when galaxies collide, and they might be an indication of a
  galaxy reaching middle age.
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