in a mighty manner; powerfully or vigorously.
to a great extent or degree; very much: to desire something mightily.

before 900; Middle English; Old English mihtiglīce. See mighty, -ly

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World English Dictionary
mightily (ˈmaɪtɪlɪ)
1.  to a great extent, amount, or degree
2.  with might; powerfully or vigorously

Collins English Dictionary - Complete & Unabridged 10th Edition
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Example sentences
Coral reefs, among other ecosystems, are suffering mightily at the hands of
Many people struggle mightily to achieve and are of course disappointed by less
  successful outcomes.
The corporate overlords would profit mightily off the carnage wreaked by faulty
  products flooding our villages and homes.
The press is working mightily to make sure that never happens.
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