an instance of bad fortune; mishap.

1250–1300; mis-1 + adventure; replacing Middle English mesaventure < Old French

1. mischance, accident; disaster, calamity, catastrophe.
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World English Dictionary
misadventure (ˌmɪsədˈvɛntʃə)
1.  an unlucky event; misfortune
2.  law accidental death not due to crime or negligence

Collins English Dictionary - Complete & Unabridged 10th Edition
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Word Origin & History

late 13c., from O.Fr. mesaventure (12c.), from mesavenir "to turn out badly;" see mis- (2) + adventure. Related: Misadventured.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
But consideration for his parents' sensibilities would have required the
  suppression of this misadventure.
There's still plenty of opportunity for misadventure.
It is the latest misadventure for a government that has been stumbling since
  its inception.
Misadventure piles on misadventure, but he bears it all with a grim
  cheerfulness and stubborn courage.
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