a combining form meaning “alone,” “single,” “one” (monogamy ); specialized in some scientific terms to denote a monomolecular thickness (monolayer ) and adapted in chemistry to apply to compounds containing one atom of a particular element (monohydrate ).
Also, especially before a vowel, mon-.

< Greek, combining form of mónos alone Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
mono- or (before a vowel) mon-
combining form
1.  one; single: monochrome; monorail
2.  indicating that a chemical compound contains a single specified atom or group: monoxide
[from Greek monos]
mon- or (before a vowel) mon-
combining form
[from Greek monos]

Collins English Dictionary - Complete & Unabridged 10th Edition
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Word Origin & History

from Gk. mono-, comb. form of monos "single, alone," from PIE base *men- "small, isolated," also represented by Gk. manos "rare, sparse," and perhaps by Eng. minnow.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

mono- or mon-

  1. One; single; alone: monomorphic.

  2. Monomolecular; monatomic: monolayer.

  3. Containing one atom, molecule, or group: monomer.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Science Dictionary
A prefix that means "one, only, single," as in monochromatic, having only one color. It is often found in chemical names where it means "containing just one" of the specified atom or group, as in carbon monoxide, which is carbon attached to a single oxygen atom.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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