|monoclonal antibody (ˌmɒnəʊˈkləʊnəl)|
|an antibody, produced by a single clone of cells grown in culture, that is both pure and specific and is capable of proliferating indefinitely to produce unlimited quantities of identical antibodies: used in diagnosis, therapy, and biotechnology|
monoclonal antibody n.
Any of a class of highly specific antibodies produced by the clones of a single hybrid cell formed in the laboratory by the fusion of a B cell with a tumor cell and widely used in medical and biological research.
antibody produced artificially by a genetic engineering technique. Production of monoclonal antibodies was one of the most important techniques of biotechnology to emerge during the last quarter of the 20th century. When activated by an antigen, a circulating B cell multiplies to form a clone of plasma cells, each secreting identical immunoglobulin molecules. It is such immunoglobulins-derived from the descendants of a single B cell-that are called monoclonal antibodies.
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