mortal sin

noun Roman Catholic Church.
a willfully committed, serious transgression against the law of God, depriving the soul of divine grace.
Compare venial sin. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
mortal sin
Christianity Compare venial sin a sin regarded as involving total loss of grace

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Example sentences
It is a mortal sin to use the tax word irrespective of the cause or worthiness
  of the need.
Another pitfall of fasting is to avoid the mortal sin of gluttony.
Writer's block, however, is a trip to the theme park of your choice alongside
  the mortal sin that produces it.
Be always ready rather to suffer all manner of torments than to commit any
  mortal sin.
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