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mulligrubs

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mul⋅li⋅grubs

[muhl-i-gruhbz]
–noun (used with a singular or plural verb) Southern U.S.
ill temper; colic; grumpiness.

Origin:
1590–1600; earlier mulligrums, appar. alter. of megrims
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2009.
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Main Entry:  mulligrubs
Part of Speech:  n
Definition:  See mubblefubbles
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Word Origin & History

mulligrubs 
"fit of the blues," also "colic," 1599, fanciful formation.
Online Etymology Dictionary, © 2001 Douglas Harper
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