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nephrosclerosis neph·ro·scle·ro·sis (něf'rō-sklə-rō'sĭs)
Induration of the kidney from overgrowth and contraction of the interstitial connective tissue.
hardening of the walls of the small arteries and arterioles (small arteries that convey blood from arteries to the even smaller capillaries) of the kidney. This condition is caused by hypertension (high blood pressure). Hypertension can be present in a person for 20 to 30 years without evidence of kidney involvement; such persons usually die of other effects of hypertension such as congestion of blood in the heart, hardening of the heart tissue, or cerebral (brain) hemorrhage. If these maladies do not occur first, there is usually some eventual renal (kidney) involvement. Nephrosclerosis is classified as either benign or malignant