causing irritation, vexation, or annoyance: to cope with a nettlesome situation.
easily provoked or annoyed: to become nettlesome over trivial matters.

1760–70; nettle + -some1 Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
nettlesome (ˈnɛtəlsəm)
causing or susceptible to irritation

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Example sentences
Causation is nearly as nettlesome a problem as contingency.
Reading and sending e-mail--even with nettlesome attachments--was a snap.
Its rise will be far more nettlesome than that of his own country a century ago.
The nettlesome fact at the heart of the matter is that expensive petrol is not
  the problem.
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