verb (used with object), optimized, optimizing.
to make as effective, perfect, or useful as possible.
to make the best of.
Computers. to write or rewrite (the instructions in a program) so as to maximize efficiency and speed in retrieval, storage, or execution.
Mathematics. to determine the maximum or minimum values of (a specified function that is subject to certain constraints).
verb (used without object), optimized, optimizing.
to be optimistic.
Also, especially British, optimise.

1835–45; optim(um) + -ize

maximize, optimize.
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
optimize or optimise (ˈɒptɪˌmaɪz)
1.  (tr) to take the full advantage of
2.  (tr) to plan or carry out (an economic activity) with maximum efficiency
3.  (intr) to be optimistic
4.  (tr) to write or modify (a computer program) to achieve maximum efficiency in storage capacity, time, cost, etc
5.  (tr) to find the best compromise among several often conflicting requirements, as in engineering design
optimise or optimise
optimi'zation or optimise
optimi'sation or optimise

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

1844, "to act as an optimist," back formation from optimist. Meaning "to make the most of" is first recorded 1857. Related: Optimization; optimisation.
Online Etymology Dictionary, © 2010 Douglas Harper
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Computing Dictionary

optimise definition

To perform optimisation.

The Free On-line Dictionary of Computing, © Denis Howe 2010 http://foldoc.org
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Example sentences
We need to optimise the design and build a fleet of these rovers.
Simply put, hypnosis is a way to optimise your ability to do what you want to
Now it will increasingly be used to automate and optimise interactions with the
  physical environment.
Each module is fitted with its own, personal electronic management system to
  optimise its charging and discharging rates.
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