n. one's pal or friend. (A variant of homes. See also Sherlock. Usually a term of address.) : What do you think about that, holmes?
Dictionary of American Slang and Colloquial Expressions by Richard A. Spears.Fourth Edition. Copyright 2007. Published by McGraw Hill.
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Science Dictionary
Holmes (hōmz, hōlmz) Pronunciation Key
British geologist who pioneered a method of determining the age of rocks by measuring their radioactive components. He was also an early supporter of Alfred Wegener's theory of continental drift.
[hohmz, hohlmz] 
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