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1570s, in Greek mythology, the first mortal woman, made by Hephaestus and given as a bride to Epimetheus, from Greek pandora "all-gifted" (or perhaps "giver of all"), from pan "all" (see pan-) + doron "gift," from PIE root *do- "to give" (see date (n.1)).
Pandora's box (1570s) refers to her gift from Zeus, which was foolishly opened by Epimetheus, upon which all the contents escaped. They were said to be the host of human ills (escaping to afflict mankind), or, in a later version, all the blessings of the god (escaping to be lost), except Hope, which alone remained.