pneumonocele pneu·mo·no·cele (n&oomacr;'mə-nō-sēl', ny&oomacr;'-, n&oobreve;-mŏn'ə-, ny&oobreve;-) n. Protrusion of a portion of the lung through a defect in the chest wall. Also called pleurocele, pneumatocele, pneumocele.